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pentobarbital will lower the level or effect of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.pentobarbital will lower the extent or outcome of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with strong CYP3A4 inducers is not advisablepentob